MR Diffusion Tractography

In this chapter we describe the underlying principles and most common techniques in diffusion tractography. We cover deterministic streamline tractography and several different probabilistic approaches. We aim to provide a conceptual understanding of the different approaches, but where necessary we introduce mathematical concepts for the more advanced reader. We further address issues of interpretation of tractography results, and of designing a tractography study. We hope the chapter covers the major themes and issues in current tractography research and will provide a reference for both users of diffusion tractography and for those researching new methodological techniques. We end with a discussion of the areas that we believe will make the most fruitful advances in tractography research in the coming years. © 2014 Elsevier Inc. All rights reserved.