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Murine cytolytic T cell lines have been analyzed for the expression of two surface glycoproteins called T145 and T130. T145, known to be expressed by activated cytolytic T cells, is also expressed by such lines, but T130, which has been described by a universal T cell marker, is not. Our results suggest a structural relationship between T145 and T130. Vicia villosa lectin, which binds selectively to T145 of activated T cells and which is cytotoxic for cytolytic T cell lines, has been used to select lectin-resistant mutants from these lines. Five independent lectin-resistant mutants have been obtained. All of them are cytolytically active, bind up to 100-fold less lectin than the parental lines, but still express T145 or a closely related glycoprotein.

Original publication

DOI

10.1002/eji.1830101111

Type

Journal article

Journal

Eur J Immunol

Publication Date

11/1980

Volume

10

Pages

860 - 868

Keywords

Animals, Binding Sites, Cell Line, Cytotoxicity, Immunologic, Electrophoresis, Polyacrylamide Gel, Glycoproteins, Lectins, Membrane Proteins, Mice, Mice, Inbred AKR, Mice, Inbred BALB C, Mutation, T-Lymphocytes