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OBJECTIVE: Neuro-imaging studies have suggested that the ability to imitate meaningless and meaningful gestures may differentially depend on superior (SPL) and inferior (IPL) parietal lobule. Therefore, we hypothesized that imaging-guided neuro-navigated continuous theta burst stimulation (cTBS) over left SPL mainly affects meaningless and over left IPL predominantly meaningful gestures. METHODS: Twelve healthy subjects participated in this study. High resolution structural MRI was used for imaging guided neuro-navigation cTBS. Participants were targeted with one train of cTBS in three experimental sessions: sham stimulation over vertex and real cTBS over left SPL and IPL, respectively. An imitation task, including 24 meaningless and 24 meaningful gestures, was performed 'offline'. RESULTS: cTBS over both left IPL and SPL significantly interfered with gestural imitation. There was no differential effect of SPL and IPL cTBS on gesture type (meaningless versus meaningful). CONCLUSIONS: Our findings confirm that left posterior parietal cortex plays a predominant role in gestural imitation. However, the hypothesis based on the dual route model suggesting a differential role of SPL and IPL in the processing of meaningless and meaningful gestures could not be confirmed. SIGNIFICANCE: Left SPL and IPL play a common role within the posterior-parietal network in gestural imitation regardless of semantic content.

Original publication

DOI

10.1016/j.clinph.2013.07.024

Type

Journal article

Journal

Clin Neurophysiol

Publication Date

03/2014

Volume

125

Pages

457 - 462

Keywords

Gestures, IPL, Imitation, SPL, Theta burst stimulation, Adult, Female, Gestures, Humans, Imitative Behavior, Magnetic Resonance Imaging, Male, Middle Aged, Parietal Lobe, Theta Rhythm, Transcranial Magnetic Stimulation, Young Adult