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PURPOSE OF REVIEW: This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs). RECENT FINDINGS: The combined use of structural biology and deep sequencing of antigen-specific B-cell lineages has allowed cross-sectional and longitudinal views of antibody evolution towards broad and potent neutralization of HIV-1. Recent advances in molecular modelling allied with protein and glycoprotein engineering have fuelled the design of new-generation viral envelope glycoproteins (Env)-based antigens. SUMMARY: Although proof-of-principle for vaccine elicitation of bNAbs to HIV-1 is still lacking, many of the conceptual hurdles are being addressed.

Original publication

DOI

10.1097/COH.0000000000000054

Type

Journal article

Journal

Curr Opin HIV AIDS

Publication Date

05/2014

Volume

9

Pages

217 - 223

Keywords

Antibodies, Neutralizing, B-Lymphocytes, HIV Antibodies, HIV Envelope Protein gp120, HIV Infections, Humans