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For the 500,000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts. K-ras, but not p53 or APC, mutations appear to be associated with poorer overall survival in colorectal cancer patients.

Original publication

DOI

10.1136/gut.2005.070946

Type

Journal article

Journal

Gut

Publication Date

09/2005

Volume

54

Pages

1209 - 1211

Keywords

Aged, Colorectal Neoplasms, DNA, Neoplasm, Female, Genes, APC, Genes, p53, Genes, ras, Humans, Male, Middle Aged, Mutation, Polymorphism, Restriction Fragment Length, Prognosis, Survival Rate