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Simulated bases set for LCModel analysis was refined using phantom metabolite spectra and highly resolved in vivo spectra from the rat brain at 9.4 T. Metabolite quantification using the new simulated basis set is in excellent agreement with the quantification performed using the experimental basis set. In addition, CRLB were significantly reduced. This update is mainly important for the weakly represented metabolites, such as Asc, Glc and GSH.


Conference paper

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Accepted - Accepted