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Water-mediated bond formation: The structure of the peptide GPG-NH2 has been investigated in aqueous solution to understand the role of water in the formation of a β-turn. Using a combination of neutron diffraction enhanced by isotopic substitution, NMR spectroscopy, and computer simulations, it was found that water is an essential component to initiate folding in solution.

Original publication

DOI

10.1002/anie.201307657

Type

Journal article

Journal

Angew Chem Int Ed Engl

Publication Date

02/12/2013

Volume

52

Pages

13091 - 13095

Keywords

hydrogen bonds, peptides, structure elucidation, water, β-turns, Hydrogen Bonding, Models, Molecular, Peptides, Protein Folding, Protein Structure, Secondary, Water