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Standard meta-analyses are an effective tool in evidence-based medicine, but one of their main drawbacks is that they can compare only two alternative treatments at a time. Moreover, if no trials exist which directly compare two interventions, it is not possible to estimate their relative efficacy. Multiple treatments meta-analyses use a meta-analytical technique that allows the incorporation of evidence from both direct and indirect comparisons from a network of trials of different interventions to estimate summary treatment effects as comprehensively and precisely as possible.

Original publication




Journal article


Epidemiol Psychiatr Sci

Publication Date





151 - 153


Combined Modality Therapy, Evidence-Based Medicine, Humans, Mental Disorders, Meta-Analysis as Topic, Psychiatry, Research Design