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delta 1-Tetrahydrocannabinol (delta 1-THC) has been quantified directly in erythrocyte membranes from drug-treated mice using gas chromatography/mass spectrometry. Concentrations of approximately 6 ng delta 1-THC/mg membrane protein (10(-5) M) were found when effects of the drug on behavior were prevalent. At these concentrations the drug produced a decrease in membrane order as measured by ESR.

Type

Journal article

Journal

Experientia

Publication Date

15/08/1984

Volume

40

Pages

866 - 868

Keywords

Animals, Behavior, Animal, Dronabinol, Erythrocyte Membrane, Kinetics, Male, Membrane Fluidity, Membrane Proteins, Mice