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This chapter discusses the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortex. Topics covered include radial migration, tangential migration, labelling techniques, and Cajal-Retzius cells. It is argued that the complexity added to the initial model of cortical development comes from the abundant populations recently discovered that use tangential migration. In turn, this reflects the intricate pattern of tangential movements during early telencephalic development. Although it was initially believed to be of little importance, this type of migration is fundamental during the earliest developmental stages.

Original publication





Book title

From Development to Degeneration and Regeneration of the Nervous System


Oxford University Press

Publication Date





Cajal-Retzius cells, Cerebral cortex, Cortical development, Neurons, Radial migration, Tangential migration, Telencephalon