Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Functional roles of ionic currents in a membrane delimited sino-atrial node (SAN) cell model were investigated. Ionic currents were blocked and intracellular calcium ([Ca2+]i) buffered to study their effects on action potential (AP) characteristics. The simulations revealed that blocking the hyperpolarization activated current and the T-type calcium current caused an increase of cycle length (CL) due to reduced diastolic depolarization rate (DDR). Blocking of sustained outward (Ist) and sodium currents ( INa,1.1, INa,1.5) had no effect. Blocking the L-type calcium current's Cav1.3 isoform (ICaL1.3) and rapidly activating delayed rectifier arrested pacemaking. Blocking sodiumcalcium exchanger (I NaCa) caused a CL reduction but did not affect DDR. Reducing [Ca 2+]i increased CL marginally. A small increase of [Ca 2+]i arrestedpacemaking. Ist, I Na1.1, and INa1.5are not functional and INaCa is a background current in the model.


Journal article


Computing in Cardiology

Publication Date





421 - 424