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Structural biology efforts in recent years have generated numerous co-crystal structures of bioactive small molecules interacting with their plant targets. These studies include the targets of various phytohormones, pathogen-derived effectors, herbicides and other bioactive compounds. Here we discuss that this collection of structures contains excellent examples of nine collective observations: molecular glues, allostery, inhibitors, molecular mimicry, promiscuous binding sites, unexpected electron densities, natural selection at atomic resolution, and applications in structure-guided mutagenesis and small molecule design.

Original publication

DOI

10.1016/j.pbi.2011.06.003

Type

Journal article

Journal

Curr Opin Plant Biol

Publication Date

10/2011

Volume

14

Pages

480 - 488

Keywords

Crystallography, X-Ray, Models, Molecular, Plant Proteins, Plants, Structure-Activity Relationship