Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Poly(ADP-ribosyl)ation is involved in the regulation of a variety of cellular pathways, including, but not limited to, transcription, chromatin, DNA damage and other stress signalling. Similar to other tightly regulated post-translational modifications, poly(ADP-ribosyl)ation employs 'writers', 'readers' and 'erasers' to confer regulatory functions. The generation of poly(ADP-ribose) is catalyzed by poly(ADP-ribose) polymerase enzymes, which use NAD(+) as a cofactor to sequentially transfer ADP-ribose units generating long polymers, which, in turn, can affect protein function or serve as a recruitment platform for additional factors. Historically, research has focused on poly(ADP-ribose) generation pathways, with knowledge about PAR recognition and degradation lagging behind. Over recent years, several discoveries have significantly furthered our understanding of poly(ADP-ribose) recognition and, even more so, of poly(ADP-ribose) degradation. In this review, we summarize current knowledge about the protein modules recognizing poly(ADP-ribose) and discuss the newest developments on the complete reversibility of poly(ADP-ribosyl)ation.

Original publication

DOI

10.1111/febs.12358

Type

Journal article

Journal

FEBS J

Publication Date

08/2013

Volume

280

Pages

3491 - 3507

Keywords

ADP-ribosylation, PAR-binding zinc finger domain, WWE domain, macrodomain, poly(ADP-ribose), poly(ADP-ribose) glycohydrolase, poly(ADP-ribose) polymerase, Amino Acid Sequence, Animals, Bacterial Proteins, Catalytic Domain, DNA Damage, Glycoside Hydrolases, Humans, Models, Molecular, Molecular Sequence Data, Poly Adenosine Diphosphate Ribose, Protein Interaction Domains and Motifs, Protein Processing, Post-Translational, Proteins, Signal Transduction