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Mapping cerebrovascular reactivity (CVR) to hypercapnia is important both clinically and for improved understanding of the haemodynamic properties of the BOLD effect. In this work, BOLD/R2 CVR was investigated by using a device which provided small, repeatable and stable steps in PETCO2, whilst maintaining a steady PETO2 level. Significant CVR was observed in both grey and white matter at both 3 and 7 T, whilst an approximately linear relationship found between R2 CVR and field strength has implications for BOLD models and calibration. Grey matter R2 CVR was 0.066+/-0.004 s(-1) mm Hg(-1) at 3 T and 0.141+/-0.008 s(-1) mm Hg(-1) at 7 T. White matter R2 CVR was 0.021+/-0.003 s(-1) mm Hg(-1) at 3 T and 0.040+/-0.007 s(-1) mm Hg(-1) at 7 T.

Original publication




Journal article



Publication Date





274 - 279


Adult, Brain, Brain Mapping, Calibration, Carbon Dioxide, Cerebrovascular Circulation, Humans, Linear Models, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Nerve Fibers, Unmyelinated, Oxygen, Oxygen Consumption, Respiration, Time Factors, Young Adult