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Both the sequence of a promoter and the position of a gene in 3D nuclear space play crucial roles in gene regulation, but few studies address their inter-relationship. Using human and viral promoters on mini-chromosomes and RNA fluorescence in situ hybridization coupled to 'high-precision' localization, we show that promoters binding the same transcription factors and responding to the same signaling pathways tend to be co-transcribed in the same transcription factories. We go on to suggest how such spatial co-association might drive co-regulation of genes under the control of similar cis-elements.

Original publication

DOI

10.1242/jcs.123653

Type

Journal article

Journal

J Cell Sci

Publication Date

01/05/2013

Volume

126

Pages

2052 - 2059

Keywords

Nuclear organization, Nuclear topography, RNA FISH, Transcription factor, Transcription factory, Animals, COS Cells, Cell Nucleus, Cercopithecus aethiops, Gene Expression Regulation, Humans, Promoter Regions, Genetic, Signal Transduction, Transcription Factors