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Circadian clocks are thought to regulate retinal physiology in anticipation of the large variation in environmental irradiance associated with the earth's rotation upon its axis. In this review we discuss some of the rhythmic events that occur in the mammalian retina, and their consequences for retinal physiology. We also review methods of tracing retinal rhythmicity in vivo and highlight the electroretinogram (ERG) as a useful technique in this field. Principally, we discuss how this technique can be used as a quick and noninvasive way of assessing physiological changes that occur in the retina over the course of the day. We highlight some important recent findings facilitated by this approach and discuss its strengths and limitations.

Type

Journal article

Journal

J Genet

Publication Date

12/2008

Volume

87

Pages

459 - 466

Keywords

Animals, Biomedical Research, Circadian Rhythm, Electroretinography, Humans, Mammals, Models, Biological, Periodicity, Retina