Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotective in models of combined oxygen/glucose deprivation and N-methyl-D-aspartate toxicity, but no potentiation was observed at low IL-1 concentrations. Both protective and toxic effects of IL-1 were fully antagonized by IL-1 receptor antagonist. These data demonstrate that the effects of IL-1 on neuronal injury are complex, and may be directly related to the injury paradigm studied.


Journal article


Neurosci Lett

Publication Date





29 - 32


Animals, Brain Ischemia, Culture Techniques, Dose-Response Relationship, Drug, Glucose, Hippocampus, Hypoxia, Interleukin 1 Receptor Antagonist Protein, Interleukin-1, N-Methylaspartate, Nerve Degeneration, Neurons, Neuroprotective Agents, Neurotoxins, Osmolar Concentration, Rats, Rats, Wistar, Sialoglycoproteins