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The principal response of many bacteria to DNA damage is mediated by a mechanism dependent on the LexA and RecA proteins. However, Mycobacterium tuberculosis was recently reported to regulate a majority of DNA repair genes independently of RecA and LexA, suggesting that an unknown RecA/LexA-independent mechanism controls the major DNA damage response pathway in this organism. Here we have identified a motif tTGTCRgtg-8nt-TAnnnT that defines a novel RecA/LexA-independent promoter (RecA-NDp) of M. tuberculosis. Furthermore, we show that the RecA-NDp type of promoter precedes DNA repair genes in other Actinomycetales.

Original publication

DOI

10.1016/j.femsle.2004.07.017

Type

Journal article

Journal

FEMS Microbiol Lett

Publication Date

01/09/2004

Volume

238

Pages

57 - 63

Keywords

Actinomycetales, Bacterial Proteins, Base Sequence, Consensus Sequence, DNA Damage, DNA Repair, Gene Expression Regulation, Bacterial, Humans, Molecular Sequence Data, Mycobacterium tuberculosis, Promoter Regions, Genetic, Rec A Recombinases, Regulon, Sequence Alignment, Serine Endopeptidases, Sigma Factor