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Brain states are dynamically shaped by distinct neuronal systems across the brain as a result of an interplay between their intrinsic activity and the environmental demand. Subsets of brainstem and forebrain structures influence the manifestation of specific brain states (e.g., sleep or wakefulness) and contribute to their cyclic alternation. Recent evidence, however, shows that such functional partition is not observed in the brainstem, where neuronal subpopulations engage in particular patterns of activity that contribute to the emergence of phasic components during the cortical slow oscillations. Cholinergic neurons of the pedunculopontine nucleus are functionally associated with the induction of the waking state but discharge during the phase of the slow oscillations that support neuronal activity. Here, we discuss the impact of the phasic signals arising from subcortical structures on the modulation of cortical slow oscillations and their functional significance.

Original publication

DOI

10.1016/B978-0-444-53839-0.00006-5

Type

Journal article

Journal

Prog Brain Res

Publication Date

2011

Volume

193

Pages

85 - 92

Keywords

Action Potentials, Animals, Cerebral Cortex, Cholinergic Neurons, Electroencephalography, Humans, Pedunculopontine Tegmental Nucleus, Periodicity, Sleep, Wakefulness