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RNA Polymerase II (Pol II) termination is dependent on RNA processing signals as well as specific terminator elements located downstream of the poly(A) site. One of the two major terminator classes described so far is the Co-Transcriptional Cleavage (CoTC) element. We show that homopolymer A/T tracts within the human β-globin CoTC-mediated terminator element play a critical role in Pol II termination. These short A/T tracts, dispersed within seemingly random sequences, are strong terminator elements, and bioinformatics analysis confirms the presence of such sequences in 70% of the putative terminator regions (PTRs) genome-wide.

Original publication

DOI

10.1093/nar/gks1335

Type

Journal article

Journal

Nucleic Acids Res

Publication Date

01/02/2013

Volume

41

Pages

1797 - 1806

Keywords

AT Rich Sequence, Base Sequence, HeLa Cells, Humans, Molecular Sequence Data, Mutation, Poly A, Poly T, RNA Cleavage, RNA Polymerase II, Terminator Regions, Genetic, Transcription Termination, Genetic, beta-Globins