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Voltage gated potassium channel (VGKC) complex antibodies are associated with encephalopathies both in adult and children. The incidence of antibodies in the central nervous system demyelinating disorders is increasingly reported although their direct pathogenic role remains to be evaluated, with the exception of Aquaporin 4 antibodies. Here we describe a case of a 28 month old boy presenting with acute disseminated encephalomyelitis, with positive VGKC-complex antibodies and low sodium levels. He was treated with steroids and made a clinical and radiological recovery with normalisation of antibody levels.

Original publication

DOI

10.1016/j.msard.2012.09.007

Type

Journal article

Journal

Mult Scler Relat Disord

Publication Date

04/2013

Volume

2

Pages

147 - 150

Keywords

Acute demyelination syndrome, Acute disseminated encephalomyelitis, Autoantibodies, Brainstem demyelination, Brainstem encephalitis, Voltage gated potassium channel complex antibodies