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The intercellular communication that regulates cell fate during animal development must be precisely controlled to avoid dangerous errors. How is this achieved? Recent work has highlighted the importance of positive and negative feedback loops in the dynamic regulation of developmental signalling. These feedback interactions can impart precision, robustness and versatility to intercellular signals. Feedback failure can cause disease.

Original publication

DOI

10.1038/35042500

Type

Journal article

Journal

Nature

Publication Date

16/11/2000

Volume

408

Pages

313 - 319

Keywords

Animals, Body Patterning, Cell Differentiation, Embryonic Development, Embryonic and Fetal Development, Feedback, Growth, Humans, Neoplasms, Signal Transduction