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The idea that morphogen gradients are established by a process of repeated cycles of exocytosis and endocytosis-so-called planar transcytosis-has been gaining acceptance. This is now challenged by a theoretical approach that experimental biologists should not dismiss; diffusive mechanisms of gradient formation may be correct after all.


Journal article


Dev Cell

Publication Date





689 - 690


Animals, Biological Transport, Body Patterning, Drosophila, Endocytosis, Exocytosis, Gene Expression Regulation, Developmental, Insect Proteins, Models, Biological, Morphogenesis, Signal Transduction, Transforming Growth Factor beta