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Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.


Journal article


Curr Opin Genet Dev

Publication Date





512 - 518


Active Transport, Cell Nucleus, Animals, Cell Communication, Cell Nucleus, Cysteine Endopeptidases, Cytoplasm, Endopeptidases, Evolution, Molecular, Humans, Intracellular Membranes, Multienzyme Complexes, Proteasome Endopeptidase Complex, Signal Transduction, Transcription Factors