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Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.

Original publication

DOI

10.1002/ajmg.b.30503

Type

Journal article

Journal

Am J Med Genet B Neuropsychiatr Genet

Publication Date

05/06/2007

Volume

144B

Pages

508 - 516

Keywords

ATP-Binding Cassette Transporters, Age of Onset, Aged, Aged, 80 and over, Alzheimer Disease, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Humans, Insulin, Intracellular Signaling Peptides and Proteins, Male, PPAR gamma, Phosphoenolpyruvate Carboxykinase (GTP), Polymorphism, Single Nucleotide, Potassium Channels, Potassium Channels, Inwardly Rectifying, Receptors, Drug, Sex Characteristics, Signal Transduction, Son of Sevenless Proteins, Sulfonylurea Receptors, United Kingdom