Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.

Original publication




Journal article


Am J Med Genet B Neuropsychiatr Genet

Publication Date





508 - 516


ATP-Binding Cassette Transporters, Age of Onset, Aged, Aged, 80 and over, Alzheimer Disease, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Humans, Insulin, Intracellular Signaling Peptides and Proteins, Male, PPAR gamma, Phosphoenolpyruvate Carboxykinase (GTP), Polymorphism, Single Nucleotide, Potassium Channels, Potassium Channels, Inwardly Rectifying, Receptors, Drug, Sex Characteristics, Signal Transduction, Son of Sevenless Proteins, Sulfonylurea Receptors, United Kingdom