Asymptomatic maternal myasthenia as a cause of the Pena-Shokeir phenotype.
Brueton LA., Huson SM., Cox PM., Shirley I., Thompson EM., Barnes PR., Price J., Newsom-Davis J., Vincent A.
We report six sibs with arthrogryposis multiplex congenita and a Pena-Shokeir phenotype, born to a healthy woman who was discovered to have asymptomatic myasthenia gravis (MG). This is the first report of anti-acetylcholine receptor (AChR) antibodies causing fetal akinesia/hypokinesia sequence in the offspring of an asymptomatic mother.