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Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecular connection between sleep, plasticity, and memory formation has been difficult to demonstrate. We establish Drosophila as a model to investigate this relation and demonstrate that the intensity and/or complexity of prior social experience stably modifies sleep need and architecture. Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3',5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes.

Original publication




Journal article



Publication Date





1775 - 1781


Animals, Brain Chemistry, Circadian Rhythm, Cyclic AMP, Dopamine, Drosophila melanogaster, Female, Hearing, Learning, Male, Memory, Models, Animal, Mutation, Sexual Behavior, Animal, Signal Transduction, Sleep, Smell, Social Environment, Social Isolation, Vision, Ocular