Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Episodic ataxias are ion channel disorders characterized by attacks of incoordination. The authors performed a genome-wide screen in a large pedigree segregating a novel episodic ataxia and found significant linkage on 1q42 with a multipoint lod score of 3.65. Haplotype analysis and fine mapping yielded a peak 2-point lod score of 4.14 and indicated a 4-cM region on 1q42 that is likely to harbor an episodic ataxia gene.

Original publication




Journal article



Publication Date





156 - 158


Adolescent, Adult, Ataxia, Child, Chromosome Mapping, Chromosomes, Human, Pair 1, DNA Mutational Analysis, Diagnosis, Differential, Female, Genetic Linkage, Genetic Markers, Genetic Predisposition to Disease, Genetic Testing, Genome, Genotype, Haplotypes, Humans, Inheritance Patterns, Lod Score, Male, Middle Aged, Mutation, Pedigree, Phenotype, Vertigo