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The macrophage is exquisitely sensitive to its microenvironment, as demonstrated primarily through in vitro study. Changes in macrophage phenotype and function within the atherosclerotic plaque have profound consequences for plaque biology, including rupture and arterial thrombosis leading to clinical events such as myocardial infarction. We review the evidence for dynamic changes in macrophage numbers and macrophage differentiation within the atherosclerotic plaque microenvironment and discuss potential approaches to target macrophage differentiation for therapeutic benefit in cardiovascular disease.

Original publication

DOI

10.1159/000336618

Type

Journal article

Journal

J Innate Immun

Publication Date

2012

Volume

4

Pages

498 - 508

Keywords

Animals, Atherosclerosis, Cell Differentiation, Cytokines, Humans, Macrophages, Mice