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Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signaling subunits that have polybasic motifs associate with the plasma membrane, and that this regulates their phosphorylation. Recent experiments in more physiological systems have confirmed membrane association but raised questions as to its function.

Original publication

DOI

10.3389/fimmu.2012.00029

Type

Journal article

Journal

Front Immunol

Publication Date

2012

Volume

3

Keywords

T cell receptor, membrane association, polybasic motifs, tyrosine phosphorylation