Preservation of cortical histamine H 3 receptors in ischemic vascular and mixed dementias
Sheng Y., Lee JH., Medhurst AD., Wilcock GK., Esiri M., Wong PTH., Chen CP., Lai MKP.
Aim: Histamine H 3 receptor antagonists have been proposed as a novel therapeutic approach for the symptomatic treatment of Alzheimer's disease (AD). However, it is unclear whether there is a neurochemical basis for extending their potential use in vascular and mixed dementias. In this study, we measured cortical H 3 receptors in patients with subcortical ischemic vascular dementia (SIVD) and mixed SIVD/AD (MIX). Materials and methods: Radioligand binding assays using [ 3 H]GSK189254 were used to measure H 3 receptors in the postmortem frontal cortex, anterior cingulate gyrus and hippocampus of a cohort of longitudinally assessed SIVD, MIX and age-matched controls. Results: H 3 receptor levels were unchanged in SIVD and MIX in all areas studied. Furthermore, frontal H 3 receptor densities negatively correlated with predeath assessment of cognition using Mini-Mental State Examination (MMSE) scores. Conclusion: Our data suggest that H 3 receptors are preserved in SIVD and MIX, thus supporting further assessments of H 3 antagonists as potential therapeutics in these dementias. © 2011 Elsevier B.V. All rights reserved.