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Whole genome sequences have shown that bacteria possess a significant number of genes that have no known function. It is probable that many of these are required for survival in environments other than the agar plate. In vivo selection strategies provide a means of obtaining genes active in complex natural environments. Direct access to these genes is essential for understanding ecological performance and provides novel opportunities for biotechnology.


Journal article


Curr Opin Biotechnol

Publication Date





440 - 444


Bacteria, Biotechnology, Ecology, Environmental Microbiology, Gene Expression, Genetic Techniques, Selection, Genetic