Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular trafficking pathways they act in.

Original publication

DOI

10.1016/j.ceb.2010.04.007

Type

Journal article

Journal

Curr Opin Cell Biol

Publication Date

08/2010

Volume

22

Pages

461 - 470

Keywords

Animals, Endocytosis, GTPase-Activating Proteins, Guanine Nucleotide Exchange Factors, Humans, Protein Transport, Secretory Pathway, rab GTP-Binding Proteins