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Monoclonal antibodies are potentially useful immunosuppressive agents. Short course of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming, reviewed by Herman Waldmann and Stephen Cobbold, is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms.


Journal article


Trends Pharmacol Sci

Publication Date





143 - 148


Animals, Antibodies, Monoclonal, Autoimmune Diseases, Graft Rejection, Humans, Immune Tolerance, Immunosuppressive Agents, Major Histocompatibility Complex, T-Lymphocytes