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By using a murine monoclonal antibody produced against an IL 2-dependent human T cell line, we defined a T lineage-specific molecule, termed Ta1, that is expressed strongly on activated T lymphocytes of both the T4 and T8 subsets, as well as on T cell lines and clones, but only weakly on a fraction of resting T cells. SDS-PAGE analysis of immunoprecipitates from 125I-labeled, activated T cells demonstrates a single major band of apparent m.w. 105 KD under both reducing and nonreducing conditions. Unlike anti-IL 2 receptor antibodies, anti-Ta1 does not inhibit T cell proliferative responses to mitogen, antigen, or IL 2-containing medium. Moreover, anti-Ta1 has no effect on T cell-mediated cytotoxicity. Ta1 appears to be a novel human T cell-specific activation antigen that may serve as a useful marker of T cell activation in human disease.

Type

Journal article

Journal

J Immunol

Publication Date

09/1984

Volume

133

Pages

1250 - 1256

Keywords

Animals, Antibodies, Monoclonal, Antigen-Antibody Reactions, Antigens, Surface, Chemical Precipitation, Epitopes, Female, Humans, Kinetics, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Molecular Weight, Phenotype, T-Lymphocytes, Tumor Necrosis Factor Receptor Superfamily, Member 7