Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the potentiatory action of MgADP. Both subunits are required to form a functional channel.

Type

Journal article

Journal

Curr Opin Neurobiol

Publication Date

06/1998

Volume

8

Pages

316 - 320

Keywords

ATP-Binding Cassette Transporters, Adenosine Triphosphate, Ion Channel Gating, Potassium Channels, Potassium Channels, Inwardly Rectifying, Receptors, Drug, Signal Transduction, Sulfonylurea Receptors