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Lymphocyte depletion has a long history in the area of therapeutic immunosuppression. CAMPATH-1H (alemtuzumab) was generated in an attempt to replace anti-lymphocyte globulins in the transplant arena. Its efficacy in killing lymphocytes has established it as a licensed drug for the management of chronic lymphocyte leukaemia. Short-term therapy with alemtuzumab has demonstrated long-term benefit in a number of autoimmune conditions. This drug has the potential to facilitate recruitment of tolerance processes so enabling drug minimization in transplantation, autoimmune and hypersensitivity diseases.

Original publication

DOI

10.1098/rstb.2005.1702

Type

Journal article

Journal

Philos Trans R Soc Lond B Biol Sci

Publication Date

29/09/2005

Volume

360

Pages

1707 - 1711

Keywords

Animals, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antibodies, Neoplasm, Graft vs Host Disease, Humans, Immune Tolerance, Lymphocyte Depletion, Models, Immunological, T-Lymphocytes