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In order to decide where to exit blood vessels and enter tissues, leukocytes roll along endothelial surfaces. Recent studies suggest that an 'automatic braking system' (ABS), involving selectin cell-adhesion molecules, enables leukocytes to roll at a fairly constant velocity despite large variations in blood flow rate.

Type

Journal article

Journal

Curr Biol

Publication Date

03/06/1999

Volume

9

Pages

R419 - R422

Keywords

Animals, Cell Adhesion, Leukocytes, Ligands, Selectins