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10 alloreactive cytotoxic T lymphocytes using REX Ti beta variable region (V) gene segments in formation of their antigen/major histocompatibility complex (MHC) T3-Ti receptor were selected, cloned, and characterized in an effort to examine the extent of receptor diversity created by this one V gene family. Multiple and distinct class II as well as class I allospecificities were generated from the formation of different Ti beta V domains. Five allospecificities were directed at various class I epitopes whereas the other five were directed at class II MHC gene products. The following conclusions were drawn: (a) Ti beta V genes do not segregate into those that encode class I and those that encode class II allospecificities; and (b) there is no restriction on the Ti beta V gene pool available to T4+ vs. T8+ T lymphocytes.

Type

Journal article

Journal

J Exp Med

Publication Date

01/10/1985

Volume

162

Pages

1387 - 1392

Keywords

Animals, Cytotoxicity, Immunologic, HLA Antigens, Histocompatibility Antigens Class II, Humans, Major Histocompatibility Complex, Receptors, Antigen, T-Cell, Sheep