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In eukaryotic cells, cellular functions are compartmentalized into membrane-bound organelles. This has many advantages, as shown by the success of the eukaryotic lineage, but creates many problems for cells, such as the need to build and partition these organelles during cell growth and division. Diverse mechanisms for biogenesis of the endoplasmic reticulum and Golgi apparatus have evolved, ranging from de novo synthesis to the copying of a template organelle. The different mechanisms by which organelles are inherited in yeasts, protozoa and metazoans probably reflect the differences in the structure and copy number of these organelles.

Original publication




Journal article


Nat Rev Mol Cell Biol

Publication Date





429 - 439


Animals, Endoplasmic Reticulum, Eukaryotic Cells, Golgi Apparatus, Saccharomyces cerevisiae