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Purkinje fibres play an important role in cardiac conduction and have been implicated in arrhythmia in presence of diseased states, genetic mutations, or adverse side effects of drugs. For these reasons, the Purkinje assay is commonly used in pre-clinical in vitro drug assessment of arrhythmic risk. Several investigators have pointed out that rabbit Purkinje cells, compared to other species, have a better sensitivity in detecting arrhythmic risk.

Original publication

DOI

10.1109/IEMBS.2010.5626614

Type

Journal article

Journal

Conf Proc IEEE Eng Med Biol Soc

Publication Date

2010

Volume

2010

Pages

2658 - 2661

Keywords

Action Potentials, Animals, Arrhythmias, Cardiac, Biophysics, Computer Simulation, Electrophysiology, Imaging, Three-Dimensional, Models, Cardiovascular, Models, Theoretical, Purkinje Cells, Rabbits, Risk, Sodium-Potassium-Exchanging ATPase, Software