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The microtubule-associated protein tau favors microtubule nucleation and stabilization and plays a role in the elongation of axons. We have investigated the ability of glycogen synthase kinase-3beta (GSK-3beta) to control tau-induced processes outgrowth. Tau-transfected Chinese hamster ovary (CHO) cells developed processes containing microtubule bundles after cytochalasin treatment, but a significant reduction in the number of cells harboring processes was observed in tau/GSK-3beta-co-transfected cells. Lithium, an inhibitor of GSK-3beta, counteracted in a dose-dependent manner this inhibitory effect of GSK-3beta. These findings suggest that GSK-3beta modulates in a graded manner the ability of tau to control the microtubule-dependent induction of cell processes.

Type

Journal article

Journal

FEBS Lett

Publication Date

07/01/2000

Volume

465

Pages

34 - 38

Keywords

Animals, CHO Cells, Calcium-Calmodulin-Dependent Protein Kinases, Cell Cycle, Cricetinae, Cytochalasin B, Enzyme Inhibitors, Glycogen Synthase Kinase 3, Glycogen Synthase Kinases, Immunoblotting, Lithium, Phosphorylation, Transfection, tau Proteins