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Computational models for cardiomyocyte action potentials (AP) often make use of a large parameter set. This parameter set can contain some elements that are fitted to experimental data independently of any other element, some elements that are derived concurrently with other elements to match experimental data, and some elements that are derived purely from phenomenological fitting to produce the desired AP output. Furthermore, models can make use of several different data sets, not always derived for the same conditions or even the same species. It is consequently uncertain whether the parameter set for a given model is physiologically accurate. Furthermore, it is only recently that the possibility of degeneracy in parameter values in producing a given simulation output has started to be addressed. In this study, we examine the effects of varying two parameters (the L-type calcium current (I(CaL)) and the delayed rectifier potassium current (I(Ks))) in a computational model of a rabbit ventricular cardiomyocyte AP on both the membrane potential (V(m)) and calcium (Ca(2+)) transient. It will subsequently be determined if there is degeneracy in this model to these parameter values, which will have important implications on the stability of these models to cell-to-cell parameter variation, and also whether the current methodology for generating parameter values is flawed. The accuracy of AP duration (APD) as an indicator of AP shape will also be assessed.

Original publication

DOI

10.1109/IEMBS.2010.5626617

Type

Journal article

Journal

Conf Proc IEEE Eng Med Biol Soc

Publication Date

2010

Volume

2010

Pages

2662 - 2665

Keywords

Action Potentials, Animals, Calcium, Calcium Signaling, Computer Simulation, Heart Ventricles, Ions, Membrane Potentials, Models, Cardiovascular, Myocytes, Cardiac, Potassium, Rabbits, Reproducibility of Results, Software, Stochastic Processes