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The Gram-positive bacterium Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. Expression of five of these factors has previously been shown to be subjected to post-transcriptional regulation as a result of their long 5'-untranslated region (5'-UTR). We have investigated the presence of 5'-UTRs among the other known virulence genes and genes that encode putatively virulence-associated surface proteins. Our results strongly suggest that L. monocytogenes controls many of its virulence genes by a mechanism that involves the 5'-UTR. These findings further emphasize the importance of post-transcriptional control for L. monocytogenes virulence.

Original publication

DOI

10.1016/j.tim.2006.05.001

Type

Journal article

Journal

Trends Microbiol

Publication Date

07/2006

Volume

14

Pages

294 - 298

Keywords

5' Untranslated Regions, Gene Expression Regulation, Bacterial, Genes, Bacterial, Listeria monocytogenes, Membrane Proteins, Models, Biological, Protein Processing, Post-Translational, Virulence Factors