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RNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5' and 3' untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules that can influence protein expression and function in response to external cues such as temperature, pH and levels of metabolites. This Review discusses the mechanisms by which these regulatory RNAs, together with accessory proteins such as RNases, control the fate of mRNAs and proteins and how this regulation influences virulence in pathogenic bacteria.

Original publication

DOI

10.1038/nrmicro2457

Type

Journal article

Journal

Nat Rev Microbiol

Publication Date

12/2010

Volume

8

Pages

857 - 866

Keywords

Bacteria, Bacterial Proteins, RNA, Antisense, RNA, Bacterial, RNA, Messenger, RNA, Untranslated