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Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.


Journal article


Infect Immun

Publication Date





2245 - 2248


Animals, Bacteremia, Bacterial Proteins, Carbon-Sulfur Lyases, Homoserine, Lactones, Neisseria meningitidis, Rats, Rats, Wistar, Virulence