Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The regulated secretion of cellular proteins is central to the correct function of many cell types, including immune cells. Lymphocyte control of the storage, transport and exocytosis of immunomodulatory molecules is a highly specialised task triggered by T cell receptor engagement. The regulated secretory pathway in CD8+ T and NK cells has been the focus of much research, and recent advances have provided insight into the molecular mechanisms governing secretory organelle biogenesis, trafficking and killing. By contrast, regulated secretory pathways in CD4+ T cells have not been studied extensively. Aside from their physiological function in normal T cells, components of CD4+ T cell secretory pathways might be implicated in the assembly of HIV-1. Here, we review findings that shed light on CD4+ T cell secretion in health and disease.

Original publication

DOI

10.1016/j.it.2007.08.008

Type

Journal article

Journal

Trends Immunol

Publication Date

11/2007

Volume

28

Pages

474 - 481

Keywords

Animals, Antigens, CD, Antigens, Differentiation, CD4-Positive T-Lymphocytes, CTLA-4 Antigen, Cytokines, Fas Ligand Protein, HIV-1, Human Immunodeficiency Virus Proteins, Humans, Killer Cells, Natural, Lysosomes, Protein Transport, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic