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No disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD.

Original publication

DOI

10.1016/j.jneuroim.2011.08.008

Type

Journal article

Journal

J Neuroimmunol

Publication Date

28/10/2011

Volume

239

Pages

91 - 97

Keywords

Adult, Animals, Autoantibodies, Behcet Syndrome, Female, Heat-Shock Proteins, Hippocampus, Humans, Male, Mannose-Binding Protein-Associated Serine Proteases, Middle Aged, Multiple Sclerosis, Nerve Degeneration, Neurons, Organ Specificity, Rats