Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The electrochemical reduction of the inhalation anaesthetic agent isoflurane was investigated at a commercially available Au microelectrode (5 μm) in DMSO solvent, individually, and also as a component of a simple vapour mixture with oxygen using both traditional voltammetric and potential step chronoamperometric techniques. In a binary gas mixture with oxygen, isoflurane is shown to react with the superoxide anion radical, formed from the electro-reduction of oxygen complicating their simultaneous detection. The observed cross-interference reaction is shown to be dependent of the electrode size and the concentration of the anaesthetic agent, isoflurane. Under steady-state conditions, and using small diameter microelectrodes (5 μm) and low isoflurane concentration ([ISO] <0.2% v/v), the superoxide/isoflurane reaction is shown to approach a one-electron process, where the coupled homogeneous reaction kinetics are almost "out-run". The use of potential step chronoamperometric techniques however, is shown to significantly reduce the deleterious cross-interference reaction between superoxide and isoflurane. In essence, this work provides scope for the development of a rapid, accurate and inexpensive electrochemical gas sensor for measuring anaesthetic vapour mixture under clinically relevant conditions. © 2004 Elsevier B.V. All rights reserved.

Original publication




Journal article


Sensors and Actuators, B: Chemical

Publication Date





200 - 208