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PURPOSE: To describe a method of fibrin glue fixation of single or multilayered amniotic membranes in sterile corneal ulceration. DESIGN: A modified microsurgical procedure. METHODS: The corneal ulcer is cleaned and the components of fibrin glue are applied separately. Amniotic membranes are rotated through the fibrinogen component and subsequently into the site of the ulceration where thrombin is already applied. An overlay membrane is sutured additionally on top. The results for one patient are illustrated as an example. RESULTS: The application technique prevents development of foam and leads to a thin fibrin film, which minimizes any irregularities of the fixed membranes and creates extra time to adjust the membranes' position. CONCLUSIONS: This method presents as an effective procedure for the treatment of sterile corneal ulceration and creates valuable time if any elective corneal graft procedure is required.

Original publication




Journal article


Am J Ophthalmol

Publication Date





189 - 191


Aged, 80 and over, Amnion, Biological Dressings, Corneal Ulcer, Female, Fibrin Tissue Adhesive, Humans, Tissue Adhesives